Background Optimal design of the rigid bronchoscope was achieved by Dr. Chevalier
Jackson of Philadelphia in 1904 when he devised a light for the distal end of the …

Current Concepts of the Pathogenesis of Sarcoidosis Page 1 Current Concepts of the
Pathogenesis of Sarcoidosis1 ,2 PD THOMAS and GW HUNNINGHAKE Contents …

Background: Lung inflammation (alveolitis) may cause lung fibrosis in scleroderma.
Objective: To determine whether cyclophosphamide treatment is associated with retention of …

Most studies of lung histology in systemic sclerosis have been based on autopsy specimens
and consequently emphasize end-stage fibrotic disease. Although occasional pathologic …

To determine the role of chemokines in the pathogenesis of systemic sclerosis (SSc), we
examined serum levels, spontaneous production by peripheral blood mononuclear cells …

Abstract purpose: Bronchoalveolar lavage (BAL) was performed in 43 nonsmoking patients
with scleroderma (systemic sclerosis) to determine the frequency of alveolitis, the status of …

Objective. This retrospective observational study attempted to determine whether any of the
therapies used in the management of systemic sclerosis (SSc) patients held potential benefit …

OBJECTIVE: To evaluate the safety and efficacy of monthly intravenous pulses of
cyclophosphamide (CP) in combination with low or high doses of prednisolone in patients …

Systemic sclerosis (SSc) is an autoimmune disorder characterized by fibrosis of the skin and
internal organs. Despite several studies on SSc treatments, effective treatments for SSc are …

Objective Substantial toxicity limits the use of daily oral cyclophosphamide (CYC) for the
treatment of interstitial lung disease (ILD) due to collagen vascular diseases. We examined …