The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …

The subcellular position of a protein is a key determinant of its function. Mounting evidence
indicates that RNA localization, where specific mRNAs are transported subcellularly and …

Current treatment approaches toward spinal cord injuries (SCI) have mainly focused on
overcoming the inhibitory microenvironment that surrounds lesion sites. Unfortunately, the …

Neurons of the peripheral nervous system retain the intrinsic capability of regenerate their
axons after injury, by triggering a complex activation response. This genetic switch is …

The human brain is one of the most complex biological systems, and the cognitive abilities
have greatly expanded compared to invertebrates without much expansion in the number of …

Schwann cells actively interact with axons of dorsal root ganglia (DRG) neurons. Exosomes
mediate intercellular communication by transferring their biomaterials, including microRNAs …

Altered levels and functions of microRNAs (miRNAs) are correlated with carcinogenesis.
While miR-409-3p has been shown to play important roles in several cancer types, its …

Subcellular targeting and local translation of mRNAs are critical for axon development.
However, the precise local control of mRNA translation requires investigation. We report that …

Peripheral nerve injuries remain problematic to treat, with poor functional recovery
commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal …

Brain injury generates the release of a multitude of factors including extracellular
nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions …