Role of oxidative modifications in atherosclerosis

R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Hydrogen sulphide and its therapeutic potential

C Szabó - Nature reviews Drug discovery, 2007 - nature.com
Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling
molecule in the cardiovascular and nervous systems. The production of H2S from l-cysteine …

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

DA Wink, JB Mitchell - Free Radical Biology and Medicine, 1998 - Elsevier
There has been confusion as to what role (s) nitric oxide (NO) has in different physiological
and pathophysiological mechanisms. Some studies imply that NO has cytotoxic properties …

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

L Jia, C Bonaventura, J Bonaventura, JS Stamler - Nature, 1996 - nature.com
A dynamic cycle exists in which haemoglobin is S-nitrosylated in the lung when red blood
cells are oxygenated, and the NO group is released during arterial–venous transit. The …

[PDF][PDF] Nitric oxide synthases: which, where, how, and why?

T Michel, O Feron - The Journal of clinical investigation, 1997 - Am Soc Clin Investig
Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present
in all mammalian cells, the sheer volume of publications on the subject might lead one to …

Chronic heart failure in the United States: a manifestation of coronary artery disease

M Gheorghiade, RO Bonow - Circulation, 1998 - Am Heart Assoc
decrease the need for cardiac transplantation. 53 These paradoxical responses have been
attributed to the fact that many inotropic and vasodilating agents enhance cardiac …

Effects of dietary nitrate on oxygen cost during exercise

FJ Larsen, E Weitzberg, JO Lundberg… - Acta …, 2007 - Wiley Online Library
Abstract Aim: Nitric oxide (NO), synthesized from l‐arginine by NO synthases, plays a role in
adaptation to physical exercise by modulating blood flow, muscular contraction and glucose …

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

S Moncada, JD Erusalimsky - Nature Reviews Molecular Cell Biology, 2002 - nature.com
The physiological role of nitric oxide (NO) in the maintenance of vascular tone, in synaptic
transmission and in cellular defence is now firmly established. Recent evidence indicates …

[HTML][HTML] Nitric oxide and mitochondrial respiration

GC Brown - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1999 - Elsevier
Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

[HTML][HTML] Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

GC Brown - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2001 - Elsevier
Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means.
Nanomolar concentrations of NO immediately, specifically and reversibly inhibit cytochrome …