TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

RY Li, Q Qin, HC Yang, YY Wang, YX Mi, YS Yin… - Molecular …, 2022 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis

Z Kavyani, V Musazadeh, S Fathi, AH Faghfouri… - International …, 2022 - Elsevier
Background Existing meta-analyses on omega-3 polyunsaturated fatty acids and their anti-
inflammatory effects have reported uncertain findings. The current umbrella meta-analysis …

[HTML][HTML] Revolutionary auxetic intravascular medical stents for angioplasty applications

MS Ebrahimi, M Noruzi, R Hamzehei, E Etemadi… - Materials & Design, 2023 - Elsevier
Due to the significant mortality rate associated with atherosclerosis-induced cardiovascular
disease, the utilization of advanced intravascular stents with superior mechanical …

Endoplasmic reticulum stress activates unfolded protein response signaling and mediates inflammation, obesity, and cardiac dysfunction: therapeutic and molecular …

OM Amen, SD Sarker, R Ghildyal, A Arya - Frontiers in pharmacology, 2019 - frontiersin.org
Obesity has been implicated as a risk factor for insulin resistance and cardiovascular
diseases (CVDs). Although the association between obesity and CVD is a well-established …

[HTML][HTML] TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury

W Wei, L Zhang, W **n, Y Pan, L Tatenhorst… - Biomedicine & …, 2024 - Elsevier
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane receptor
protein predominantly expressed in microglia within the central nervous system (CNS) …

Materials for immunotherapy

CW Shields IV, LLW Wang, MA Evans… - Advanced …, 2020 - Wiley Online Library
Breakthroughs in materials engineering have accelerated the progress of immunotherapy in
preclinical studies. The interplay of chemistry and materials has resulted in improved …

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc

V Madhu, M Hernandez-Meadows, PK Boneski, Y Qiu… - Autophagy, 2023 - Taylor & Francis
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been
overlooked. We have shown that NP cells contain networked mitochondria and that …

Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

OS Ademowo, HKI Dias, DGA Burton, HR Griffiths - Biogerontology, 2017 - Springer
Lipids are essential for physiological processes such as maintaining membrane integrity,
providing a source of energy and acting as signalling molecules to control processes …

The association between metabolic syndrome components and the development of atherosclerosis

A Aboonabi, RR Meyer, I Singh - Journal of human hypertension, 2019 - nature.com
Metabolic syndrome (MetS) is a collection of pathological conditions associated with
metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the …

Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis

H Ait-Oufella, AP Sage, Z Mallat, A Tedgui - Circulation research, 2014 - ahajournals.org
Chronic inflammation in response to lipoprotein accumulation in the arterial wall is central in
the development of atherosclerosis. Both innate and adaptive immunity are involved in this …