The pathogenesis of the antiphospholipid syndrome
B Giannakopoulos, SA Krilis - New England Journal of Medicine, 2013 - Mass Medical Soc
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …
Getting to the outer leaflet: physiology of phosphatidylserine exposure at the plasma membrane
EM Bevers, PL Williamson - Physiological reviews, 2016 - journals.physiology.org
Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …
distribution between inner and outer leaflets is an important physiological signal. Normally …
Vaccines, adjuvants and autoimmunity
LE Guimarães, B Baker, C Perricone… - Pharmacological …, 2015 - Elsevier
Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host
immune response against an antigen can elicit a memory T-cell response over time …
immune response against an antigen can elicit a memory T-cell response over time …
[HTML][HTML] The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS
T McDonnell, C Wincup, I Buchholz, C Pericleous… - Blood reviews, 2020 - Elsevier
Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …
Annexin A2 heterotetramer: structure and function
A Bharadwaj, M Bydoun, R Holloway… - International journal of …, 2013 - mdpi.com
Annexin A2 is a pleiotropic calcium-and anionic phospholipid-binding protein that exists as
a monomer and as a heterotetrameric complex with the plasminogen receptor protein …
a monomer and as a heterotetrameric complex with the plasminogen receptor protein …
β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome
Ç Ağar, GMA van Os, M Mörgelin… - Blood, The Journal …, 2010 - ashpublications.org
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …
Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome
The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic
autoantibodies against β2-glycoprotein-I (β2GPI). The factors causing production of anti …
autoantibodies against β2-glycoprotein-I (β2GPI). The factors causing production of anti …
A Fluoroquinolone Resistance Protein from Mycobacterium tuberculosis That Mimics DNA
SS Hegde, MW Vetting, SL Roderick, LA Mitchenall… - Science, 2005 - science.org
Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The
expression of MfpA, a member of the pentapeptide repeat family of proteins from …
expression of MfpA, a member of the pentapeptide repeat family of proteins from …
[HTML][HTML] β2‐Glycoprotein I: evolution, structure and function
PG De Groot, JCM Meijers - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …
Automatically fixing errors in glycoprotein structures with Rosetta
Recent advances in single-particle cryo-electron microscopy (cryoEM) have resulted in
determination of an increasing number of protein structures with resolved glycans. However …
determination of an increasing number of protein structures with resolved glycans. However …