Approaches for bacteriophage genome engineering

M Mahler, AR Costa, SPB van Beljouw… - Trends in …, 2023 - cell.com
In recent years, bacteriophage research has been boosted by a rising interest in using
phage therapy to treat antibiotic-resistant bacterial infections. In addition, there is a desire to …

Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing

BA Adler, T Hessler, BF Cress, A Lahiri, VK Mutalik… - Nature …, 2022 - nature.com
CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming
RNA and DNA phages by binding to complementary target phage transcripts followed by …

Genetic engineering of bacteriophages against infectious diseases

Y Chen, H Batra, J Dong, C Chen, VB Rao… - Frontiers in …, 2019 - frontiersin.org
Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth,
constituting a virtually unlimited resource to explore the development of biomedical …

The many applications of engineered bacteriophages—An overview

B Gibb, P Hyman, CL Schneider - Pharmaceuticals, 2021 - mdpi.com
Since their independent discovery by Frederick Twort in 1915 and Felix d'Herelle in 1917,
bacteriophages have captured the attention of scientists for more than a century. They are …

Engineering bacteriophages as versatile biologics

S Kilcher, MJ Loessner - Trends in microbiology, 2019 - cell.com
Viruses of bacteria (bacteriophages or phages) are highly evolved nanomachines that
recognize bacterial cell walls, deliver genetic information, and kill or transform their targets …

Application of bacteriophages in the agro-food sector: A long way toward approval

L Fernández, D Gutiérrez, A Rodríguez… - Frontiers in cellular and …, 2018 - frontiersin.org
The rapid increase in multi-drug resistant (MDR) pathogens has put notable pressure on
Health Authorities, who foresee an uncertain future for global human health. In June 2017 …

Progress and prospect: Biosynthesis of plant natural products based on plant chassis

J Lin, X Yin, Y Zeng, X Hong, S Zhang, B Cui… - Biotechnology …, 2023 - Elsevier
Plant-derived natural products are a specific class of active substances with numerous
applications in the medical, energy, and industrial fields. Many of these substances are in …

Bacteriophage and endolysin engineering for biocontrol of food pathogens/pathogens in the food: recent advances and future trends

C Lee, H Kim, S Ryu - CritiCal reviews in Food sCienCe and …, 2023 - Taylor & Francis
Despite advances in modern technologies, various foodborne outbreaks have continuously
threatened the food safety. The overuse of and abuse/misuse of antibiotics have escalated …

Engineering Phages to Fight Multidrug-Resistant Bacteria

H Peng, IA Chen, U Qimron - Chemical Reviews, 2024 - ACS Publications
Facing the global “superbug” crisis due to the emergence and selection for antibiotic
resistance, phages are among the most promising solutions. Fighting multidrug-resistant …