Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy
Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …
Sex differences and similarities in valvular heart disease
JT DesJardin, J Chikwe, RT Hahn, JW Hung… - Circulation …, 2022 - Am Heart Assoc
As populations age worldwide, the burden of valvular heart disease has grown
exponentially, and so has the proportion of affected women. Although rheumatic valve …
exponentially, and so has the proportion of affected women. Although rheumatic valve …
Staging classification of aortic stenosis based on the extent of cardiac damage
Aims In patients with aortic stenosis (AS), risk stratification for aortic valve replacement
(AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to …
(AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to …
Aortic valve stenosis: from basic mechanisms to novel therapeutic targets
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
Calcific aortic valve disease: mechanisms, prevention and treatment
Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …
Why and how to measure aortic valve calcification in patients with aortic stenosis
The first-line evaluation of aortic stenosis severity is Doppler echocardiography. However, in
up to 40% of patients, resting echocardiographic assessment of aortic stenosis severity is …
up to 40% of patients, resting echocardiographic assessment of aortic stenosis severity is …
Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study
Objective Transitions in the spectrum of valvular heart diseases (VHDs) in developed
countries over the 20th century have been reported from clinical case series, but large …
countries over the 20th century have been reported from clinical case series, but large …
Cardiac imaging for assessing low-gradient severe aortic stenosis
Up to 40% of patients with aortic stenosis (AS) harbor discordant Doppler-
echocardiographic findings, the most common of which is the presence of a small aortic …
echocardiographic findings, the most common of which is the presence of a small aortic …
Vitamin K2 and D in patients with aortic valve calcification: a randomized double-blinded clinical trial
Background: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the
carboxylation of proteins involved in the inhibition of arterial calcification and has been …
carboxylation of proteins involved in the inhibition of arterial calcification and has been …
Multi-modality imaging in aortic stenosis: an EACVI clinical consensus document
In this EACVI clinical scientific update, we will explore the current use of multi-modality
imaging in the diagnosis, risk stratification, and follow-up of patients with aortic stenosis, with …
imaging in the diagnosis, risk stratification, and follow-up of patients with aortic stenosis, with …