Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy

S Kraler, MC Blaser, E Aikawa, GG Camici… - European heart …, 2022 - academic.oup.com
Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Sex differences and similarities in valvular heart disease

JT DesJardin, J Chikwe, RT Hahn, JW Hung… - Circulation …, 2022 - Am Heart Assoc
As populations age worldwide, the burden of valvular heart disease has grown
exponentially, and so has the proportion of affected women. Although rheumatic valve …

Staging classification of aortic stenosis based on the extent of cardiac damage

P Généreux, P Pibarot, B Redfors, MJ Mack… - European heart …, 2017 - academic.oup.com
Aims In patients with aortic stenosis (AS), risk stratification for aortic valve replacement
(AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to …

Aortic valve stenosis: from basic mechanisms to novel therapeutic targets

PR Goody, MR Hosen, D Christmann… - … , and vascular biology, 2020 - Am Heart Assoc
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …

Calcific aortic valve disease: mechanisms, prevention and treatment

LHM Moncla, M Briend, Y Bossé… - Nature Reviews Cardiology, 2023 - nature.com
Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Why and how to measure aortic valve calcification in patients with aortic stenosis

T Pawade, T Sheth, E Guzzetti, MR Dweck… - JACC: Cardiovascular …, 2019 - jacc.org
The first-line evaluation of aortic stenosis severity is Doppler echocardiography. However, in
up to 40% of patients, resting echocardiographic assessment of aortic stenosis severity is …

Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study

P Andell, X Li, A Martinsson, C Andersson, M Stagmo… - Heart, 2017 - heart.bmj.com
Objective Transitions in the spectrum of valvular heart diseases (VHDs) in developed
countries over the 20th century have been reported from clinical case series, but large …

Cardiac imaging for assessing low-gradient severe aortic stenosis

MA Clavel, IG Burwash, P Pibarot - JACC: Cardiovascular Imaging, 2017 - jacc.org
Up to 40% of patients with aortic stenosis (AS) harbor discordant Doppler-
echocardiographic findings, the most common of which is the presence of a small aortic …

Vitamin K2 and D in patients with aortic valve calcification: a randomized double-blinded clinical trial

ACP Diederichsen, JS Lindholt, S Möller, KA Øvrehus… - Circulation, 2022 - Am Heart Assoc
Background: Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the
carboxylation of proteins involved in the inhibition of arterial calcification and has been …

Multi-modality imaging in aortic stenosis: an EACVI clinical consensus document

MR Dweck, K Loganath, R Bing… - European Heart …, 2023 - academic.oup.com
In this EACVI clinical scientific update, we will explore the current use of multi-modality
imaging in the diagnosis, risk stratification, and follow-up of patients with aortic stenosis, with …