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The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Zinc finger proteins in neuro-related diseases progression
S Bu, Y Lv, Y Liu, S Qiao, H Wang - Frontiers in neuroscience, 2021 - frontiersin.org
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …
Concise review: balancing stem cell self-renewal and differentiation with PLZF
In recent years, the highly conserved promyelocytic leukemia zinc finger (PLZF, also known
as ZBTB16, ZNF145) has attracted attention as a multifunctional transcription factor involved …
as ZBTB16, ZNF145) has attracted attention as a multifunctional transcription factor involved …
UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE): a master regulator of sialic acid synthesis
Abstract UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is the key
enzyme of sialic acid biosynthesis in vertebrates. It catalyzes the first two steps of the …
enzyme of sialic acid biosynthesis in vertebrates. It catalyzes the first two steps of the …
The angiotensin II type 2 receptor in brain functions: an update
Angiotensin II (Ang II) is the main active product of the renin‐angiotensin system (RAS),
mediating its action via two major receptors, namely, the Ang II type 1 (AT1) receptor and the …
mediating its action via two major receptors, namely, the Ang II type 1 (AT1) receptor and the …
[HTML][HTML] Functions of the (pro) renin receptor (Atp6ap2) at molecular and system levels: pathological implications in hypertension, renal and brain development …
N Hoffmann, J Peters - Pharmacological Research, 2021 - Elsevier
Abstract The (pro) renin receptor [(P) RR, Atp6ap2] was initially discovered as a membrane-
bound binding partner of prorenin and renin. A soluble (P) RR has additional paracrine …
bound binding partner of prorenin and renin. A soluble (P) RR has additional paracrine …
How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?
The angiotensin type 2 (AT2) receptor of angiotensin II has long been thought to be limited
to few tissues, with the primary effect of counteracting the angiotensin type 1 (AT1) receptor …
to few tissues, with the primary effect of counteracting the angiotensin type 1 (AT1) receptor …
Angiotensin II type 2 receptor agonists: where should they be applied?
Introduction: Angiotensin II, the active endproduct of the renin–angiotensin system (RAS),
exerts its effects via angiotensin II type 1 and type 2 (AT1, AT2) receptors. AT1 receptors …
exerts its effects via angiotensin II type 1 and type 2 (AT1, AT2) receptors. AT1 receptors …
Increase of zinc finger protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease
Reactive astrogliosis is a cellular manifestation of neuroinflammation and occurs in
response to all forms and severities of the central nervous system (CNS)'s injury and …
response to all forms and severities of the central nervous system (CNS)'s injury and …
The (pro) renin receptor ((P) RR) can act as a repressor of Wnt signalling
The (pro) renin receptor ((P) RR) and Wnt signalling are both involved in different diseases
ranging from cardiac and renal end-organ damage to cancer.(P) RR function involves …
ranging from cardiac and renal end-organ damage to cancer.(P) RR function involves …