Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca2+
homoeostasis are common features in many lysosomal storage diseases. Mucolipin …

Membrane fusion and fission events in intracellular trafficking are controlled by both
intraluminal Ca2+ release and phosphoinositide (PIP) signalling. However, the molecular …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Transient receptor potential mucolipin 1 (TRPML1) is a cation channel located within
endosomal and lysosomal membranes. Ubiquitously expressed in mammalian cells,, its loss …

Abstract Members of the Transient Receptor Potential-Mucolipin (TRPML) constitute a family
of evolutionarily conserved cation channels that function predominantly in endolysosomal …

Efficient functioning of lysosome is necessary to ensure the correct performance of a variety
of intracellular processes such as degradation of cargoes coming from the endocytic and …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …