When gastrointestinal stromal tumour (GIST), the most common form of sarcoma, was first
recognized as a distinct pathological entity in the 1990s, patients with advanced-stage …

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the
gastrointestinal tract. The majority are sporadic, solitary tumors that harbor mutually …

Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that
occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic …

The role of genetic components in cancer development is an area of interest for cancer
biologists in general. Intriguingly, some genes have both oncogenic and tumor-suppressor …

The classification “gastrointestinal stromal tumor”(GIST) became commonplace in the 1990s
and since that time various advances have characterized the GIST lineage of origin, tyrosine …

The discovery of activated KIT mutations in gastrointestinal (GI) stromal tumors (GISTs) in
1998 triggered a sea change in our understanding of these tumors and has ushered in a …

Sarcomas are a rare group of mesenchymal cancers comprising over 70 different
histological subtypes. For the majority of these diseases, the molecular understanding of the …

Mutational analysis guides therapeutic decision making in patients with advanced‐stage
gastrointestinal stromal tumors (GISTs). We evaluated three targeted next‐generation …

Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal
tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological …

Purpose: The majority of gastrointestinal stromal tumors (GIST) are driven by KIT, PDGFRA,
or, less commonly, BRAF mutations, and SDH gene inactivation is involved in a limited …