Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review

VC Romão, JE Fonseca - Frontiers in medicine, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Genetic and environmental risk factors for rheumatoid arthritis

KD Deane, MK Demoruelle, LB Kelmenson… - Best practice & research …, 2017 - Elsevier
Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

RC Brewer, TV Lanz, CR Hale… - Science translational …, 2023 - science.org
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …

Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review

KH Lee, A Kronbichler, DDY Park, YM Park, H Moon… - Autoimmunity …, 2017 - Elsevier
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the
membranes of activated neutrophils. NETs are found in a variety of conditions such as …

Interaction between the gut microbiome and mucosal immune system

N Shi, N Li, X Duan, H Niu - Military Medical Research, 2017 - Springer
The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play
important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is …

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of develo** seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis

N Petrovská, K Prajzlerová, J Vencovský, L Šenolt… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis

R Khandpur, C Carmona-Rivera… - Science translational …, 2013 - science.org
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but
formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

J González‐Febles, M Sanz - Periodontology 2000, 2021 - Wiley Online Library
Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined
respectively by the destruction of the articular cartilage and tooth‐supporting periodontal …

Autoantibodies in rheumatoid arthritis: historical background and novel findings

MV Sokolova, G Schett, U Steffen - Clinical reviews in allergy & …, 2022 - Springer
Autoantibodies represent a hallmark of rheumatoid arthritis (RA), with the rheumatoid factor
(RF) and antibodies against citrullinated proteins (ACPA) being the most acknowledged …