Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

BackgroundThis review aimed to address the question of whether cognitive impairment
should be considered a core feature of depression that may be a valuable target for …

Importance Cognitive deficits in depression have been associated with poor functional
capacity, frontal neural circuit dysfunction, and worse response to conventional …

Cognitive impairments are now widely acknowledged as an important aspect of major
depressive disorder (MDD), and it has been proposed that executive function (EF) may be …

Anxiety disorders constitute a sizeable worldwide health burden with profound social and
economic consequences. The symptoms are wide-ranging; from hyperarousal to difficulties …

The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of
behaviours (including the decision to execute actions); indeed, imaging and lesion studies …

Complex emotional, cognitive and self‐reflective functions rely on the activation and
connectivity of large‐scale neural circuits. These circuits offer a relevant scale of focus for …

Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising
predictor of treatment response in depression, but neither the reliability of this relationship …

BackgroundWhen challenged with information about the future, healthy participants show an
optimistically biased updating pattern, taking desirable information more into account than …

Objective: A large number of studies with considerably variable methods have been
performed to investigate brain regions involved in the pathophysiology of major depressive …