Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to
their potential cost-effectiveness, scalability and on-demand availability. However, immune …

IFN-γ, a soluble cytokine being produced by T lymphocytes, macrophages, mucosal
epithelial cells, or natural killer cells, is able to bind to the IFN-γ receptor (IFNγR) and in turn …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

The majority of colorectal cancer patients are not responsive to immune checkpoint
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …

Simple Summary Interferons are cytokines that play key roles in the activation of cellular
components of the immune response, such as dendritic cells, macrophages and T cells …

Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …

Antigen presentation defects in tumors are prevalent mechanisms of adaptive immune
evasion and resistance to cancer immunotherapy, whereas how tumors evade innate …

Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in
cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has …