The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective
with a mission to develop, test, distribute and promote software for macromolecular …

Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination
with ritonavir, is used to treat infections by severe acute respiratory syndrome coronavirus-2 …

The insulin-linked polymorphic region is a variable number of tandem repeats region of DNA
in the promoter of the insulin gene that regulates transcription of insulin. This region is …

The conserved Ndc80 kinetochore complex, Ndc80c, is the principal link between mitotic
spindle microtubules and centromere-associated proteins. We used AlphaFold 2 (AF2) to …

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that
causes severe viral hemorrhagic fever and thrombocytopenia syndrome with a fatality rate of …

There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes
by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and …

Cas12g is an endonuclease belonging to the type V RNA-guided CRISPR–Cas family. It is
known for its ability to cleave RNA substrates using a conserved endonuclease active site …

Infectious protein crystals are an essential part of the viral lifecycle for double-stranded DNA
Baculoviridae and double-stranded RNA cypoviruses. These viral protein crystals, termed …

Lytic polysaccharide monooxygenases (LPMOs) are surface-active redox enzymes that
catalyze the degradation of recalcitrant polysaccharides, making them important tools for …

PINK1 and Parkin mutations lead to the early onset of Parkinson's disease. PINK1-mediated
phosphorylation of ubiquitin (Ub), ubiquitin-like protein (NEDD8), and ubiquitin-like (Ubl) …