Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that
obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to …