Glioblastomas are heterogeneous and invariably lethal tumours. They are characterized by
genetic and epigenetic variations among tumour cells, which makes the development of …

Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer
vesicles that are released from cells. While initially observed in immune cells and …

Exosomes are membranous structures secreted by nearly all cell types. As critical
messengers for intercellular communication, exosomes deliver bioactive cargoes to …

Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in
the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their …

Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …

Background To understand the ability of gliomas to manipulate their microenvironment, we
visualized the transfer of vesicles and the effects of tumor-released extracellular RNA on the …

The discovery of extracellular vesicles (EVs) has revised the interpretation of intercellular
communication. It is now well established that EVs play a significant role in coagulation …

Glioblastomas (GBM) are the most frequent and aggressive malignant primary brain tumor
and remains a therapeutic challenge: even after multimodal therapy, median survival of …