Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target
S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …
developed countries, and atherosclerosis (AS) is the common pathological basis of many …
Immunothrombosis and thromboinflammation in host defense and disease
Platelets are increasingly being recognized for playing roles beyond thrombosis and
hemostasis. Today we know that they mediate inflammation by direct interactions with innate …
hemostasis. Today we know that they mediate inflammation by direct interactions with innate …
Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk
Normal platelet function is critical to blood hemostasis and maintenance of a closed
circulatory system. Heightened platelet reactivity, however, is associated with …
circulatory system. Heightened platelet reactivity, however, is associated with …
Inhalable stem cell exosomes promote heart repair after myocardial infarction
BACKGROUND: Exosome therapy shows potential for cardiac repair after injury. However,
intrinsic challenges such as short half-life and lack of clear targets hinder the clinical …
intrinsic challenges such as short half-life and lack of clear targets hinder the clinical …
[HTML][HTML] Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
I Erlund, R Koli, G Alfthan, J Marniemi, P Puukka… - The American journal of …, 2008 - Elsevier
Background: Berries are a particularly rich source of polyphenols. They also contain other
bioactive substances, such as vitamin C. Previous studies indicated that the consumption of …
bioactive substances, such as vitamin C. Previous studies indicated that the consumption of …
von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes
von Willebrand factor (VWF) plays a pivotal role in platelet adhesion and aggregation at
sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured …
sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured …
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized …
ContextNo specifically designed studies have addressed the role of the glycoprotein IIb/IIIa
inhibitor abciximab in patients with non–ST-segment elevation acute coronary syndromes …
inhibitor abciximab in patients with non–ST-segment elevation acute coronary syndromes …
Cangrelor, tirofiban, and chewed or standard prasugrel regimens in patients with st-segment–elevation myocardial infarction: primary results of the FABOLUS …
Background: Standard administration of newer oral P2Y12 inhibitors, including prasugrel or
ticagrelor, provides suboptimal early inhibition of platelet aggregation (IPA) in patients with …
ticagrelor, provides suboptimal early inhibition of platelet aggregation (IPA) in patients with …
Platelet function testing in cardiovascular diseases
AD Michelson - Circulation, 2004 - Am Heart Assoc
e489 20% of patients with an arterial thrombotic event who are treated with aspirin have a
recurrent arterial thrombotic event during long-term follow-up. 14 The failure of aspirin to …
recurrent arterial thrombotic event during long-term follow-up. 14 The failure of aspirin to …
Clinical utility of the PFA-100
The PFA-100 (platelet function analyzer) is a relatively new tool for the investigation of
primary hemostasis. This article reviews the history of the PFA-100 and details its clinical …
primary hemostasis. This article reviews the history of the PFA-100 and details its clinical …