Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Functional dimerization of serotonin receptors: role in health and depressive disorders
EV Mitroshina, EA Marasanova… - International journal of …, 2023 - mdpi.com
Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …
cAMP-PKA signaling pathway and anxiety: where do we go next?
D Chen, J Wang, J Cao, G Zhu - Cellular Signalling, 2024 - Elsevier
Cyclic adenosine monophosphate (cAMP) is an intracellular second messenger that is
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …
Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating …
M McDew-White, E Lee, LS Premadasa… - Journal of …, 2023 - Springer
Background Although the advent of combination anti-retroviral therapy (cART) has
transformed HIV into a manageable chronic disease, an estimated 30–50% of people living …
transformed HIV into a manageable chronic disease, an estimated 30–50% of people living …
Rolipram ameliorates memory deficits and depression-like behavior in APP/PS1/tau triple transgenic mice: involvement of neuroinflammation and apoptosis via cAMP …
YF Cong, FW Liu, L Xu, SS Song… - International Journal …, 2023 - academic.oup.com
Background Alzheimer disease (AD) and depression often cooccur, and inhibition of
phosphodiesterase-4 (PDE4) has been shown to ameliorate neurodegenerative illness …
phosphodiesterase-4 (PDE4) has been shown to ameliorate neurodegenerative illness …
Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder
H Hori, H Fukushima, T Nagayoshi, R Ishikawa… - Molecular …, 2024 - nature.com
Posttraumatic stress disorder (PTSD) is a psychiatric disorder associated with traumatic
memory, yet its etiology remains unclear. Reexperiencing symptoms are specific to PTSD …
memory, yet its etiology remains unclear. Reexperiencing symptoms are specific to PTSD …
[HTML][HTML] Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease which accounts for
the most cases of dementia worldwide. Impaired memory, including acquisition …
the most cases of dementia worldwide. Impaired memory, including acquisition …
[HTML][HTML] Epac: new emerging cAMP-binding protein
K Lee - BMB reports, 2021 - ncbi.nlm.nih.gov
The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the
morphology and physiology of neurons and thus higher cognitive brain functions. The …
morphology and physiology of neurons and thus higher cognitive brain functions. The …
Citrus flavonoid 3, 5, 6, 7, 8, 3′, 4′-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells
A Sawamoto, S Okuyama, M Nakajima… - Pharmacological …, 2019 - Elsevier
Background Brain-derived neurotrophic factor (BDNF) is associated with onset of several
central nervous system disorders, eg, Parkinson's disease, Alzheimer's disease, depression …
central nervous system disorders, eg, Parkinson's disease, Alzheimer's disease, depression …
[HTML][HTML] EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury
SC Berkey, JJ Herrera, MA Odem, S Rahman… - Neurobiology of Pain, 2020 - Elsevier
Chronic pain following spinal cord injury (SCI) is associated with electrical hyperactivity
(spontaneous and evoked) in primary nociceptors. Cyclic adenosine monophosphate …
(spontaneous and evoked) in primary nociceptors. Cyclic adenosine monophosphate …