Self-inspired learning for denoising live-cell super-resolution microscopy

L Qu, S Zhao, Y Huang, X Ye, K Wang, Y Liu, X Liu… - Nature …, 2024‏ - nature.com
Every collected photon is precious in live-cell super-resolution (SR) microscopy. Here, we
describe a data-efficient, deep learning-based denoising solution to improve diverse SR …

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

C Qiao, Y Zeng, Q Meng, X Chen, H Chen… - Nature …, 2024‏ - nature.com
Computational super-resolution methods, including conventional analytical algorithms and
deep learning models, have substantially improved optical microscopy. Among them …

Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo

T Yu, X Zhong, D Li, J Zhu, VV Tuchin, D Zhu - Advanced Drug Delivery …, 2024‏ - Elsevier
Advanced optical imaging provides a powerful tool for the structural and functional analysis
of tissues with high resolution and contrast, but the imaging performance decreases as light …

Self-supervised denoising for multimodal structured illumination microscopy enables long-term super-resolution live-cell imaging

X Chen, C Qiao, T Jiang, J Liu, Q Meng, Y Zeng… - PhotoniX, 2024‏ - Springer
Detection noise significantly degrades the quality of structured illumination microscopy (SIM)
images, especially under low-light conditions. Although supervised learning based …

Computational optical imaging: on the convergence of physical and digital layers

Z Wang, Y Peng, L Fang, L Gao - Optica, 2025‏ - opg.optica.org
Optical imaging has traditionally relied on hardware to fulfill its imaging function, producing
output measures that mimic the original objects. Developed separately, digital algorithms …

Robust self-supervised denoising of voltage imaging data using CellMincer

B Wang, T Ma, T Chen, T Nguyen, E Crouse… - npj Imaging, 2024‏ - nature.com
Voltage imaging is a powerful technique for studying neuronal activity, but its effectiveness is
often constrained by low signal-to-noise ratios (SNR). Traditional denoising methods, such …

Multi-color fluorescence live-cell imaging in Dictyostelium discoideum

H Hashimura, S Kuwana, H Nakagawa… - Cell Structure and …, 2024‏ - jstage.jst.go.jp
The cellular slime mold Dictyostelium discoideum, a member of the Amoebozoa, has been
extensively studied in cell and developmental biology. D. discoideum is unique in that they …

PNR: Physics-informed Neural Representation for high-resolution LFM reconstruction

J Zhao, Z Zhao, J Wu, T Yu, H Qiao - arxiv preprint arxiv:2409.18223, 2024‏ - arxiv.org
Light field microscopy (LFM) has been widely utilized in various fields for its capability to
efficiently capture high-resolution 3D scenes. Despite the rapid advancements in neural …

Self-inspired learning to denoise for live-cell super-resolution microscopy

L Qu, S Zhao, Y Huang, X Ye, K Wang, Y Liu, X Liu… - bioRxiv, 2024‏ - biorxiv.org
Every collected photon is precious in live-cell super-resolution (SR) fluorescence
microscopy for contributing to breaking the diffraction limit with the preservation of temporal …

Unsupervised multi-animal tracking for quantitative ethology

Y Li, X Li, Q Zhang, Y Zhang, J Fan, Z Lu, Z Li, J Wu… - bioRxiv, 2025‏ - biorxiv.org
Quantitative ethology necessitates accurate tracking of animal locomotion, especially for
population-level analyses involving multiple individuals. However, current methods rely on …