Heat shock proteins (HSPs) constitute a large family of conserved proteins acting as
molecular chaperones that play a key role in intracellular protein homeostasis, regulation of …

As an endoplasmic reticulum heat shock protein (HSP) 90 paralogue, glycoprotein (gp) 96
possesses immunological properties by chaperoning antigenic peptides for activation of T …

Canonically PD-L1 functions as the inhibitory immune checkpoint on cell surface. Recent
studies have observed PD-L1 expression in the nucleus of cancer cells. But the biological …

The 94 kDa molecular chaperone, glucose‐regulated protein 94 (Grp94), has garnered
interest during the last decade due to its direct association with endoplasmic reticulum (ER) …

Breast cancer is the leading cause of cancer-related fatalities in female worldwide. Effective
therapies with low side effects for breast cancer treatment and prevention are, accordingly …

Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …

Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of
the cancer cell population enters a resistant, dormant state, persists long-term in this …

Targeted gene therapy has led to significant breakthroughs in cancer treatment. Heat shock
protein gp96 is an emerging target for tumor treatment because of its transfer ability from …

The aim of the present study was to investigate the potential prognostic value of members of
the heat shock protein (HSP) 90 family in non‑small cell lung cancer (NSCLC) patients. The …

The DNA damage response involves coordinated control of gene expression and DNA
repair. Using deep sequencing, we found widespread changes of alternative cleavage and …