[HTML][HTML] miR-122–a key factor and therapeutic target in liver disease
Being the largest internal organ of the human body with the unique ability of self-
regeneration, the liver is involved in a wide variety of vital functions that require highly …
regeneration, the liver is involved in a wide variety of vital functions that require highly …
MicroRNAs in development and disease
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
Treatment of HCV infection by targeting microRNA
Background The stability and propagation of hepatitis C virus (HCV) is dependent on a
functional interaction between the HCV genome and liver-expressed microRNA-122 (miR …
functional interaction between the HCV genome and liver-expressed microRNA-122 (miR …
Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90
Antibodies targeting receptor-mediated entry of HCV into hepatocytes confer limited
therapeutic benefits. Evidence suggests that exosomes can transfer genetic materials …
therapeutic benefits. Evidence suggests that exosomes can transfer genetic materials …
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
RE Lanford, ES Hildebrandt-Eriksen, A Petri… - Science, 2010 - science.org
The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA
accumulation in cultured liver cells, but its potential as a target for antiviral intervention has …
accumulation in cultured liver cells, but its potential as a target for antiviral intervention has …
[PDF][PDF] Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis
C Roderburg, GW Urban, K Bettermann, M Vucur… - …, 2011 - Wiley Online Library
Liver fibrosis is orchestrated by a complex network of signaling pathways regulating the
deposition of extracellular matrix proteins during fibrogenesis. MicroRNAs (miRNAs) …
deposition of extracellular matrix proteins during fibrogenesis. MicroRNAs (miRNAs) …
Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma
J Hou, L Lin, W Zhou, Z Wang, G Ding, Q Dong, L Qin… - Cancer cell, 2011 - cell.com
The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to
be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and …
be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and …
Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
MicroRNAs miR-122, miR-34a, miR-16 and miR-21 are commonly deregulated in liver
fibrosis and hepatocellular carcinoma. This study examined whether circulating levels of …
fibrosis and hepatocellular carcinoma. This study examined whether circulating levels of …
Liver-specific microRNA-122: Biogenesis and function
C Jopling - RNA biology, 2012 - Taylor & Francis
microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is
highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 …
highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 …
Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer
A Allegra, A Alonci, S Campo… - International …, 2012 - spandidos-publications.com
MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs
have been implicated in different areas such as the immune response, neural development …
have been implicated in different areas such as the immune response, neural development …