Strategies to boost antibody selectivity in oncology
V Blay, A Pandiella - Trends in Pharmacological Sciences, 2024 - cell.com
Antibodies in oncology are being equipped with toxic cargoes and effector functions that can
kill cells at very low concentrations. A key challenge is that most targets on cancer cells are …
kill cells at very low concentrations. A key challenge is that most targets on cancer cells are …
Nanobody engineering: computational modelling and design for biomedical and therapeutic applications
Nanobodies, the smallest functional antibody fragment derived from camelid heavy‐chain‐
only antibodies, have emerged as powerful tools for diverse biomedical applications. In this …
only antibodies, have emerged as powerful tools for diverse biomedical applications. In this …
From Non-Affinity to High-Affinity: Rapid Preparation of Nanobodies Utilizing High-Precision AlphaFold and Structural-Interaction Analysis for Detection of Enrofloxacin …
G Li, C Liu, S Qiu, L Wei, L Cao, K Wang… - Journal of Hazardous …, 2025 - Elsevier
Traditional antibody preparation methods rely on animal immunization and experimental
screening, often requiring 3-6 months, which cannot meet the urgent demands for antibodies …
screening, often requiring 3-6 months, which cannot meet the urgent demands for antibodies …
Inference and design of antibody specificity: from experiments to models and back
Exquisite binding specificity is essential for many protein functions but is difficult to engineer.
Many biotechnological or biomedical applications require the discrimination of very similar …
Many biotechnological or biomedical applications require the discrimination of very similar …