Fibronectin is an extracellular matrix protein that is present during periods of change within
tissues. It is upregulated and necessary in a number of developmental contexts, and it is …

Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles
during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is …

Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit
intracellular stress to their environment. We here review the more recently discovered role of …

For any given animal, the sources of mechanical disturbances inducing tissue deformation
define environment from the perspective of the animal's haptic perceptual system. The …

Although studies in vivo revealed promising results in bone regeneration after implantation
of scaffolds together with osteogenic progenitor cells, basic questions remain how material …

Osteogenesis imperfecta, or brittle bone disease, is a congenital disease that primarily
causes low bone mass and bone fractures but it can negatively affect other organs. It is …

In the past few years a great deal of progress has been made in studying the mechanical
and structural properties of biological protein fibers. Here, we compare and review the …

Abstract Fibrillin-1 and fibrillin-2 are large cysteine-rich glycoproteins that serve two key
physiological functions: as supporting structures that impart tissue integrity and as regulators …

Physical forces drive the movement of tissues within the early embryo. Classical and modern
approaches have been used to infer and, in rare cases, measure mechanical properties and …

The extracellular matrix plays a key role in organ formation and tissue homeostasis. Recent
studies have revealed that fibrillin assemblies (microfibrils) confer both tissue integrity and …