Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Lung disease is the major cause of morbidity and mortality in patients with cystic fibrosis
(CF). Although CF lung disease is primarily an infectious disorder, the associated …

Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and
associated damaging products in the airway. Delayed neutrophil apoptosis is described in …

Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal
protease which can promote degradation of damaged or unwanted proteins in the endo …

Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

Neutrophil-derived proteases are critical to the pathology of many inflammatory lung
diseases, both chronic and acute. These abundant enzymes play roles in key neutrophil …

End-stage renal disease (ESRD), the last stage of chronic kidney disease (CKD), is
characterized by chronic inflammation and oxidative stress. Neutrophils are the front line …

Chronic lung disease has become a leading cause of death in recent years. Despite several
attempts to discover and develop new therapeutic approaches, patients often suffer a poor …

The airway epithelium works as a physical barrier between the external environment and
internal structures, which represent the lung's first defense against inhaled microorganisms …

Cystic fibrosis (CF) is an autosomal recessive genetic condition, predominantly of white
populations, that impacts multiple organ systems. However, it is the chronic progressive lung …