Understanding asthma phenotypes, endotypes, and mechanisms of disease
ME Kuruvilla, FEH Lee, GB Lee - Clinical reviews in allergy & immunology, 2019 - Springer
The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …
biological network of distinct and interrelating inflammatory pathways. The term asthma is …
Severe and difficult-to-treat asthma in adults
Severe and Difficult-to-Treat Asthma in Adults | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …
content The New England Journal of Medicine homepage Advanced Search SEARCH …
Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
Mechanisms and therapeutic strategies for non‐T2 asthma
E Sze, A Bhalla, P Nair - Allergy, 2020 - Wiley Online Library
Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …
Use of precision cut lung slices as a translational model for the study of lung biology
G Liu, C Betts, DM Cunoosamy, PM Åberg… - Respiratory …, 2019 - Springer
Animal models remain invaluable for study of respiratory diseases, however, translation of
data generated in genetically homogeneous animals housed in a clean and well-controlled …
data generated in genetically homogeneous animals housed in a clean and well-controlled …
Pathophysiological mechanisms of asthma
A Bush - Frontiers in pediatrics, 2019 - frontiersin.org
The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …
IL-17 cytokines and chronic lung diseases
IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …
Adult‐onset eosinophilic airway diseases
K Asano, S Ueki, M Tamari, Y Imoto, S Fujieda… - Allergy, 2020 - Wiley Online Library
Eosinophilic airway inflammation is one of the cardinal features of allergic airway diseases
such as atopic asthma and allergic rhinitis. These childhood‐onset conditions are mediated …
such as atopic asthma and allergic rhinitis. These childhood‐onset conditions are mediated …
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children
Respiratory infections are common precursors to asthma exacerbations in children, but
molecular immune responses that determine whether and how an infection causes an …
molecular immune responses that determine whether and how an infection causes an …
[HTML][HTML] Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-
6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) …
6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) …