Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …

Biological systems function through complex interactions between various 'omics
(biomolecules), and a more complete understanding of these systems is only possible …

INTRODUCTION Resolving the molecular details of proteome variation in the different
tissues and organs of the human body would greatly increase our knowledge of human …

Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …

Global classification of the human proteins with regards to spatial expression patterns
across organs and tissues is important for studies of human biology and disease. Here, we …

The availability of human genome sequence has transformed biomedical research over the
past decade. However, an equivalent map for the human proteome with direct …

Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition …

Figure 1 PeptideShaker data-analysis cycle.(a) Data generated in-house or publicly
available from PRIDE can be used as input.(b) The sequence database is selected in …

Proteomes are characterized by large protein-abundance differences, cell-type-and time-
dependent expression patterns and post-translational modifications, all of which carry …

Until recently, the only ways to reduce specific protein signaling were to either knock down
the target by RNAi or to interfere with the signaling by inhibiting an enzyme or receptor …