Several studies suggest that psychological factors are associated with negative outcomes
and in particular higher mortality rates among heart failure (HF) patients. We aimed to …

Randomized clinical trials (RCTs) are usually the preferred strategy with which to generate
evidence of comparative effectiveness, but conducting an RCT is not always feasible …

Background Treatment guidelines recommend the use of inhaled long-acting
bronchodilators to alleviate symptoms and reduce the risk of exacerbations in patients with …

Importance Patients diagnosed with localized prostate cancer have to decide among
treatment strategies that may differ in their likelihood of adverse effects. Objective To …

Purpose Despite initial treatment with surgical resection, radiotherapy, and chemotherapy,
glioblastoma multiforme (GBM) virtually always recurs. Surgery is sometimes recommended …

Patient-reported outcomes (PRO) are questionnaire measures of patients' symptoms,
functioning, and health-related quality of life. They are designed to provide important clinical …

Objective New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting
trials with mortality reduction as the end point supporting their adoption is challenging. We re …

Importance Clinical trials are essential to cancer care, and data about the current state of
research in oncology are needed to develop benchmarks and set the stage for improvement …

Background Varied and fragmented care plans undertaken by different practitioners
currently expose surgical patients to lapses in expected care, increase the chance for …

Background Needle aponeurotomy and collagenase injection are alternative treatments of
Dupuytren's contracture to open partial fasciectomy; however, reported data are difficult to …