Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Skeletal muscle force production is increased at longer compared to shorter muscle lengths
because of length-dependent priming of thick filament proteins in the contractile unit before …

Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …

There is a growing awareness that both thick-filament and classical thin-filament regulations
play central roles in modulating muscle contraction. Myosin ATPase assays have …

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …

Mavacamten is a FDA-approved small-molecule therapeutic designed to regulate cardiac
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …

Structural and functional studies of heart muscle are important to gain insights into the
physiological bases of cardiac muscle contraction and the pathological bases of heart …

Sufficient cardiac contractility is necessary to ensure the sufficient cardiac output to provide
an adequate end-organ perfusion. Inadequate cardiac output and the diminished perfusion …

Hypertension is a major cause of morbidity and mortality in patients with hypertrophic
cardiomyopathy (HCM), suggesting a potential role for mechanics in HCM pathogenesis …

In muscle, titin proteins connect myofilaments together and are thought to be critical for
contraction, especially during residual force enhancement (RFE) when steady-state force is …