Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

Defensins: The natural peptide antibiotic

X Gao, J Ding, C Liao, J Xu, X Liu, W Lu - Advanced drug delivery reviews, 2021 - Elsevier
Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

Defensins: a double-edged sword in host immunity

D Xu, W Lu - Frontiers in immunology, 2020 - frontiersin.org
Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …

Human antimicrobial peptides as therapeutics for viral infections

A Ahmed, G Siman-Tov, G Hall, N Bhalla, A Narayanan - Viruses, 2019 - mdpi.com
Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

Immunomodulatory and allergenic properties of antimicrobial peptides

SV Guryanova, TV Ovchinnikova - International journal of molecular …, 2022 - mdpi.com
With the growing problem of the emergence of antibiotic-resistant bacteria, the search for
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …

Adenovirus entry: from infection to immunity

UF Greber, JW Flatt - Annual review of virology, 2019 - annualreviews.org
More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

α‐Defensins in human innate immunity

RI Lehrer, W Lu - Immunological reviews, 2012 - Wiley Online Library
Defensins are small, multifunctional cationic peptides. They typically contain six conserved
cysteines whose three intramolecular disulfides stabilize a largely β‐sheet structure. This …

Antiviral mechanisms of human defensins

SS Wilson, ME Wiens, JG Smith - Journal of molecular biology, 2013 - Elsevier
Defensins are an effector component of the innate immune system with broad antimicrobial
activity. Humans express two types of defensins, α-and β-defensins, which have antiviral …

Insect antiviral innate immunity: pathways, effectors, and connections

MB Kingsolver, Z Huang, RW Hardy - Journal of molecular biology, 2013 - Elsevier
Insects are infected by a wide array of viruses some of which are insect restricted and
pathogenic, and some of which are transmitted by biting insects to vertebrates. The medical …

Innate immunity to adenovirus

R Hendrickx, N Stichling, J Koelen, L Kuryk… - Human gene …, 2014 - liebertpub.com
Human adenoviruses are the most widely used vectors in gene medicine, with applications
ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side …