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Appreciating force and shape—the rise of mechanotransduction in cell biology
Although the shapes of organisms are encoded in their genome, the developmental
processes that lead to the final form of vertebrates involve a constant feedback between …
processes that lead to the final form of vertebrates involve a constant feedback between …
Overview of the muscle cytoskeleton
CA Henderson, CG Gomez, SM Novak… - Comprehensive …, 2017 - pmc.ncbi.nlm.nih.gov
Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …
Genetics of dilated cardiomyopathy: practical implications for heart failure management
AN Rosenbaum, KE Agre, NL Pereira - Nature Reviews Cardiology, 2020 - nature.com
Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …
provide prognostic information are critical to reducing the morbidity and mortality associated …
Clinical and mechanistic insights into the genetics of cardiomyopathy
Over the last quarter-century, there has been tremendous progress in genetics research that
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM …
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM …
Zebrafish as a model to study cardiac development and human cardiac disease
Over the last decade, the zebrafish has entered the field of cardiovascular research as a
new model organism. This is largely due to a number of highly successful small-and large …
new model organism. This is largely due to a number of highly successful small-and large …
Mechanotransduction in cardiac hypertrophy and failure
Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …
through a process known as mechanotransduction. In the heart, this process involves the …
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …
Dilated cardiomyopathy: the complexity of a diverse genetic architecture
Remarkable progress has been made in understanding the genetic basis of dilated
cardiomyopathy (DCM). Rare variants in> 30 genes, some also involved in other …
cardiomyopathy (DCM). Rare variants in> 30 genes, some also involved in other …
Genetic mutations and mechanisms in dilated cardiomyopathy
Genetic mutations account for a significant percentage of cardiomyopathies, which are a
leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac …
leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac …