Genomic data are ubiquitous across disciplines, from agriculture to biodiversity, ecology,
evolution and human health. However, these datasets often contain noise or errors and are …

The population of Russia consists of more than 150 local ethnicities. The ethnic diversity and
geographic origins, which extend from eastern Europe to Asia, make the population …

Population allele frequency is crucially important for accurate interpretation of known and
novel variants in medical genetics. Recently, several large allele frequency databases, such …

We performed a targeted sequencing of 242 clinically important genes mostly associated
with cardiovascular diseases in a representative population sample of 1,658 individuals …

There are more than 260 million people of Slavic descent worldwide, who reside mainly in
Eastern Europe but also represent a noticeable share of the population in the USA and …

Documenting genome diversity is important for the local biomedical communities and
instrumental in develo** precision and personalized medicine. Currently, tens of …

Genetic data plays an increasingly important role in modern medicine. Decrease in the cost
of sequencing with subsequent increase in imputation accuracy, and the accumulation of …

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disorder characterized
by marked clinical and genetic heterogeneity. Ethnic groups underrepresented in studies …

Background Allele frequency data from large exome and genome aggregation projects such
as the Genome Aggregation Database (gnomAD) are of ultimate importance to the …

Cystic fibrosis, phenylketonuria, alpha-1 antitrypsin deficiency, and sensorineural hearing
loss are among the most common autosomal recessive diseases, which require carrier …