Assessment of the emerging threat posed by perfluoroalkyl and polyfluoroalkyl substances to male reproduction in humans

L Calvert, MP Green, GN De Iuliis, MD Dun… - Frontiers in …, 2022 - frontiersin.org
Per-fluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic
fluorinated chemicals used widely in industry and consumer products. Due to their extensive …

Bubbling beyond the barrier: exosomal RNA as a vehicle for soma–germline communication

D Phillips, D Noble - The Journal of Physiology, 2024 - Wiley Online Library
Abstract 'Weismann's barrier'has restricted theories of heredity to the transmission of
genomic variation for the better part of a century. However, the discovery and elucidation of …

Quercetin alleviates acrylamide-induced liver injury by inhibiting autophagy-dependent ferroptosis

T Huang, K Zhang, J Wang, K He… - Journal of Agricultural …, 2023 - ACS Publications
Acrylamide (ACR) generated in carbohydrate-rich foods during thermal processing has
been demonstrated to exhibit hepatotoxicity. As one of the most consumed flavonoids with …

Role of small RNAs harbored by sperm in embryonic development and offspring phenotype

C Yang, QX Zeng, JC Liu, WSB Yeung, JV Zhang… - …, 2023 - Wiley Online Library
Background RNA harbored by mammalian sperm is increasingly considered to be an
additional source of paternal hereditary information, beyond DNA. Recent studies have …

The emerging role of extracellular vesicles in the testis

Y Ma, QW Ma, Y Sun, XF Chen - Human Reproduction, 2023 - academic.oup.com
Extracellular vesicles (EVs) are nano-sized membrane-bounded particles, released by all
cells and capable of transporting bioactive cargoes, proteins, lipids, and nucleic acids, to …

New horizons in human sperm selection for assisted reproduction

B Nixon, JE Schjenken, ND Burke… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a commonly encountered pathology that is estimated to be a contributory
factor in approximately 50% of couples seeking recourse to assisted reproductive …

Exposure to acrylamide induces zygotic genome activation defects of mouse embryos

SL Wu, JQ Ju, YM Ji, HL Zhang, YJ Zou… - Food and Chemical …, 2023 - Elsevier
Acrylamide (ACR) is an important chemical raw material for wastewater treatment, paper
industry and textile industry, which is widely exposed from occupational, environmental and …

Cocaine-induced changes in sperm Cdkn1a methylation are associated with cocaine resistance in male offspring

SE Swinford-Jackson, B Fant, ME Wimmer… - Journal of …, 2022 - Soc Neuroscience
Paternal environmental perturbations can influence the physiology and behavior of
offspring. For example, our previous work showed reduced cocaine reinforcement in male …

[HTML][HTML] Prevention of Pregnancy Complications Using a Multimodal Lifestyle, Screening, and Medical Model

J Parker, P Hofstee, S Brennecke - Journal of Clinical Medicine, 2024 - mdpi.com
Prevention of pregnancy complications related to the “great obstetrical syndromes”(
preeclampsia, fetal growth restriction, spontaneous preterm labor, and stillbirth) is a global …

Dietary sugar shifts mitochondrial metabolism and small RNA biogenesis in sperm

R Ramesh, S Skog, L Örkenby… - Antioxidants & Redox …, 2023 - liebertpub.com
Aims: Increasing concentrations of dietary sugar results in a linear accumulation of
triglycerides in male Drosophila, while inducing a U-shaped obesity response in their …