Cancer immunotherapy is revolutionizing oncology. However, dose-limiting toxicities and
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …

Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner
that is more specific than using small-molecule drugs; however, unlike traditional drugs …

Nitric oxide and its production by iNOS is an established mechanism critical to tumor
promotion or suppression. Macrophages have important roles in immunity, development …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

Solid tumors elicit a detectable immune response including the infiltration of tumor-
associated macrophages (TAMs). Unfortunately, this immune response is co-opted into …

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A …

Glioblastoma‐associated macrophages (GAMs) play a crucial role in the progression and
invasiveness of glioblastoma multiforme (GBM); however, the exact crosstalk between GAMs …

Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately
deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile …