[HTML][HTML] Oxindole and its derivatives: A review on recent progress in biological activities
Oxindole has been shown to be a pharmacologically advantageous scaffold having many
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
Benzimidazole scaffold as anticancer agent: synthetic approaches and structure–activity relationship
Cancer, also known as malignant neoplasm, is a dreadful disease which involves abnormal
cell growth having the potential to invade or spread to other parts of the body …
cell growth having the potential to invade or spread to other parts of the body …
A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
[HTML][HTML] Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: a new insight into nanomedicine based combinational …
Cancer stem cells (CSCs) are the promising targets for cancer chemotherapy that cannot be
eliminated by conventional chemotherapy. In this study cationic liposomes of cabazitaxel …
eliminated by conventional chemotherapy. In this study cationic liposomes of cabazitaxel …
An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles
Cycloaddition reactions are of great interest due to their potential and rapid construction of
optically enriched spiro-cyclic products. 3-Methyleneindolinones have been proven to be a …
optically enriched spiro-cyclic products. 3-Methyleneindolinones have been proven to be a …
Discovery of oxindole‐based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation
FMS‐like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid
leukemia (AML) patients. In the current study, the oxindole chemotype is employed as a …
leukemia (AML) patients. In the current study, the oxindole chemotype is employed as a …
Conventional and microwave-assisted synthesis of new 1H-benzimidazole-thiazolidinedione derivatives: A potential anticancer scaffold
A series of new benzimidazole bearing thiazolidinedione derivatives has been designed,
synthesized by using conventional as well as microwave-assisted methods. Microwave …
synthesized by using conventional as well as microwave-assisted methods. Microwave …
Synthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents
A series of new benzimidazole-thiazolidinedione hybrids has been synthesized and
evaluated for their cytotoxic potential against a selected human cancer cell lines of prostate …
evaluated for their cytotoxic potential against a selected human cancer cell lines of prostate …
Syntheses and applications of spirocyclopropyl oxindoles: a decade review
AP Sakla, P Kansal… - European Journal of …, 2021 - Wiley Online Library
Spirocyclopropyl oxindole represents an emerging framework by unique amalgamation of
versatile 2‐oxindole motif and highly strained cyclopropane unit. This scaffold is remarkable …
versatile 2‐oxindole motif and highly strained cyclopropane unit. This scaffold is remarkable …