Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Immunity, atherosclerosis and cardiovascular disease

J Frostegård - BMC medicine, 2013 - Springer
Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory
condition with immune competent cells in lesions producing mainly pro-inflammatory …

The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes

S Mallick, A Micco, M Mah, H Ringbauer, I Lazaridis… - Scientific Data, 2024 - nature.com
More than two hundred papers have reported genome-wide data from ancient humans.
While the raw data for the vast majority are fully publicly available testifying to the …

Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry

M Hajdinjak, F Mafessoni, L Skov, B Vernot, A Hübner… - Nature, 2021 - nature.com
Modern humans appeared in Europe by at least 45,000 years ago,,,–, but the extent of their
interactions with Neanderthals, who disappeared by about 40,000 years ago, and their …

Dairying, diseases and the evolution of lactase persistence in Europe

RP Evershed, G Davey Smith, M Roffet-Salque… - Nature, 2022 - nature.com
Abstract In European and many African, Middle Eastern and southern Asian populations,
lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over …

The genomic history of the Iberian Peninsula over the past 8000 years

I Olalde, S Mallick, N Patterson, N Rohland… - Science, 2019 - science.org
We assembled genome-wide data from 271 ancient Iberians, of whom 176 are from the
largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect …

[HTML][HTML] The Prevotella copri complex comprises four distinct clades underrepresented in westernized populations

A Tett, KD Huang, F Asnicar, H Fehlner-Peach… - Cell host & …, 2019 - cell.com
Prevotella copri is a common human gut microbe that has been both positively and
negatively associated with host health. In a cross-continent meta-analysis exploiting> 6,500 …

The Beaker phenomenon and the genomic transformation of northwest Europe

I Olalde, S Brace, ME Allentoft, I Armit, K Kristiansen… - Nature, 2018 - nature.com
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and
central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled …

Genomic insights into the origin of farming in the ancient Near East

I Lazaridis, D Nadel, G Rollefson, DC Merrett… - Nature, 2016 - nature.com
We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time
between~ 12,000 and 1,400 bc, from Natufian hunter–gatherers to Bronze Age farmers. We …

Genome-wide patterns of selection in 230 ancient Eurasians

I Mathieson, I Lazaridis, N Rohland, S Mallick… - Nature, 2015 - nature.com
Ancient DNA makes it possible to observe natural selection directly by analysing samples
from populations before, during and after adaptation events. Here we report a genome-wide …