Microbial evolution and transitions along the parasite–mutualist continuum
Virtually all plants and animals, including humans, are home to symbiotic microorganisms.
Symbiotic interactions can be neutral, harmful or have beneficial effects on the host …
Symbiotic interactions can be neutral, harmful or have beneficial effects on the host …
Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Persistence and reversal of plasmid-mediated antibiotic resistance
In the absence of antibiotic-mediated selection, sensitive bacteria are expected to displace
their resistant counterparts if resistance genes are costly. However, many resistance genes …
their resistant counterparts if resistance genes are costly. However, many resistance genes …
Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing
Antimicrobial resistance (AMR) is a global problem hindering treatment of bacterial
infections, rendering many aspects of modern medicine less effective. AMR genes (ARGs) …
infections, rendering many aspects of modern medicine less effective. AMR genes (ARGs) …
Plasmid persistence: costs, benefits, and the plasmid paradox
Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as
well as in other domains of life. Nonetheless, the evolutionary processes underlying the …
well as in other domains of life. Nonetheless, the evolutionary processes underlying the …
Plasmid-mediated bioaugmentation for the bioremediation of contaminated soils
Bioaugmentation, or the inoculation of microorganisms (eg, bacteria harboring the required
catabolic genes) into soil to enhance the rate of contaminant degradation, has great …
catabolic genes) into soil to enhance the rate of contaminant degradation, has great …
Why are rhizobial symbiosis genes mobile?
Rhizobia are one of the most important and best studied groups of bacterial symbionts. They
are defined by their ability to establish nitrogen-fixing intracellular infections within plant …
are defined by their ability to establish nitrogen-fixing intracellular infections within plant …
A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacteria carrying mcr-1-bearing IncI2 plasmids
J Yang, HH Wang, Y Lu, LX Yi, Y Deng… - Nucleic Acids …, 2021 - academic.oup.com
The plasmid-encoded colistin resistance gene mcr-1 challenges the use of polymyxins and
poses a threat to public health. Although IncI2-type plasmids are the most common vector for …
poses a threat to public health. Although IncI2-type plasmids are the most common vector for …
Vertical and horizontal gene transfer tradeoffs direct plasmid fitness
Plasmid fitness is directed by two orthogonal processes—vertical transfer through cell
division and horizontal transfer through conjugation. When considered individually …
division and horizontal transfer through conjugation. When considered individually …
Mathematical models of plasmid population dynamics
With plasmid-mediated antibiotic resistance thriving and threatening to become a serious
public health problem, it is paramount to increase our understanding of the forces that …
public health problem, it is paramount to increase our understanding of the forces that …