Histone exchange, chromatin structure and the regulation of transcription
The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
Liquid–liquid phase separation in chromatin
K Rippe - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT
During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
Recycling of modified H2A-H2B provides short-term memory of chromatin states
Chromatin landscapes are disrupted during DNA replication and must be restored faithfully
to maintain genome regulation and cell identity. The histone H3-H4 modification landscape …
to maintain genome regulation and cell identity. The histone H3-H4 modification landscape …
Cell volume change through water efflux impacts cell stiffness and stem cell fate
Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …
a role in determining cell function and can even influence stem cell fate. Here, we identify a …
Dynamic organization of chromatin domains revealed by super-resolution live-cell imaging
T Nozaki, R Imai, M Tanbo, R Nagashima, S Tamura… - Molecular cell, 2017 - cell.com
The eukaryotic genome is organized within cells as chromatin. For proper information
output, higher-order chromatin structures can be regulated dynamically. How such structures …
output, higher-order chromatin structures can be regulated dynamically. How such structures …
[HTML][HTML] Structure of a backtracked hexasomal intermediate of nucleosome transcription
During gene transcription, RNA polymerase II (RNA Pol II) passes nucleosomes with the
help of various elongation factors. Here, we show that RNA Pol II achieves efficient …
help of various elongation factors. Here, we show that RNA Pol II achieves efficient …
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
L Li, L Shi, S Yang, R Yan, D Zhang, J Yang… - Nature …, 2016 - nature.com
Although SIRT7 is a member of sirtuin family proteins that are described as NAD+-
dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein …
dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein …
Transcription in living cells: molecular mechanisms of bursting
Transcription in several organisms from certain bacteria to humans has been observed to be
stochastic in nature: toggling between active and inactive states. Periods of active nascent …
stochastic in nature: toggling between active and inactive states. Periods of active nascent …
Pioneer transcription factors, chromatin dynamics, and cell fate control
Among the diverse transcription factors that are necessary to elicit changes in cell fate, both
in embryonic development and in cellular reprogramming, a subset of factors are capable of …
in embryonic development and in cellular reprogramming, a subset of factors are capable of …