Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Background The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-
dependent manner in responses to variety of stresses that are common in cancers. We focus …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene
expression post-transcriptionally. These non-coding regulatory RNAs become functional …

Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …

tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are
abundant small RNAs reported to be associated with Argonaute proteins, yet their function is …

Abstract MicroRNAs (miRNAs) are∼ 21-nucleotide-long regulatory RNAs that arise from
endonucleolytic processing of hairpin precursors. Many function as essential …