Chromosome Division in Early Embryos—Is Everything under Control? And Is the Cell Size Important?

A Horakova, M Konecna, M Anger - International Journal of Molecular …, 2024 - mdpi.com
Chromosome segregation in female germ cells and early embryonic blastomeres is known
to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of …

Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis

R Pun, BJ North - Frontiers in Cell and Developmental Biology, 2025 - frontiersin.org
The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven
segregation of sister chromatids between daughter cells during anaphase. This essential …

Cell cycle progression defects and impaired DNA damage signaling drive enlarged cells into senescence

S Manohar, ME Estrada, F Uliana, GE Neurohr - BioRxiv, 2022 - biorxiv.org
Cellular senescence plays an important role in development, ageing, and cancer biology.
Senescence is associated with increased cell size, but how this contributes to permanent …

[PDF][PDF] Chromosome Division during Embryogenesis–Is Everything under Control? And Does the Size Really Matter?

A Horakova, M Konecna, M Anger - 2023 - preprints.org
Chromosome segregation in female germ cells and early embryonic blastomeres is known
to be highly prone to errors. The resulting aneuploidy is therefore the most frequent reason …