Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant
cells under conditions that are lethal to the majority of the population. Stress tolerance is …

Paclitaxel is an anti-microtubule agent that has been shown to induce cell death in gastric
cancer. However, the detailed mechanism of action is unclear. In this study, we reveal that …

The posttranslational modifications (PTMs) of microtubules have been reported to play an
important role in cancer aggressiveness, including apoptosis resistance. In this study, we …

Cells experiencing delays in mitotic progression are prone to undergo apoptosis unless they
can exit mitosis before proapoptotic factors reach a critical threshold. Microtubule targeting …

Anti-microtubule therapy represents one of the most strategic cancer therapeutics. Tublin
inhibitor such as paclitaxel (PTX) is well known to disturb the dynamic nature of …

Melanoma harboring BRAF mutations frequently develop resistance to BRAF inhibitors,
limiting the impact of treatment. Here, we establish a mechanism of resistance and …

Metastatic melanoma has been described as a highly aggressive cancer with low sensibility
to chemotherapeutic agents. New types of drug, such as metal-based drugs (ferrocifens) …