Myocarditis is defined as an inflammation of the cardiac muscle. In humans, various
infectious and non-infectious triggers induce myocarditis with a broad spectrum of …

Chagas disease (CD) is a tropical neglected illness, affecting mainly populations of low
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …

The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …

The sirtuin 1 (SIRT1) activator resveratrol has emerged as a promising candidate for the
prevention of vascular oxidative stress, which is a trigger for endothelial dysfunction …

Resveratrol (RES) has been demonstrated to be protective in the cardiovascular system in
animal studies, but the evidence is limited in humans. The purpose of the study was to …

Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

Small molecules (less than 1,500 Da) include major biological signals that mediate host-
pathogen-microbiome communication. They also include key intermediates of metabolism …

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …

5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and
pathological conditions. AMPK is involved in energy metabolism, which is perturbed by …

Introduction Chagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi)
infection, is a major contributor to heart failure in Latin America. There are significant gaps in …