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Klebsiella species: Taxonomy, hypervirulence and multidrug resistance
Members of the genus Klebsiella have rapidly evolved within the past decade, generating
organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR …
organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR …
Monitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challenges
Antimicrobial resistance (AMR) is a growing threat to human and animal health. Progress in
molecular biology has revealed new and significant challenges for AMR mitigation given the …
molecular biology has revealed new and significant challenges for AMR mitigation given the …
Mobile genetic elements associated with antimicrobial resistance
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …
increasing major health care problem around the world. It is now abundantly clear that both …
Completing bacterial genome assemblies with multiplex MinION sequencing
Illumina sequencing platforms have enabled widespread bacterial whole genome
sequencing. While Illumina data is appropriate for many analyses, its short read length limits …
sequencing. While Illumina data is appropriate for many analyses, its short read length limits …
Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria
Horizontal gene transfer (HGT) and gene duplication are often considered as separate
mechanisms driving the evolution of new functions. However, the mobile genetic elements …
mechanisms driving the evolution of new functions. However, the mobile genetic elements …
A review of SHV extended-spectrum β-lactamases: neglected yet ubiquitous
β-lactamases are the primary cause of resistance to β-lactams among members of the family
Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections …
Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections …
IS26 and the IS26 family: versatile resistance gene movers and genome reorganizers
In Gram-negative bacteria, the insertion sequence IS 26 is highly active in disseminating
antibiotic resistance genes. IS 26 can recruit a gene or group of genes into the mobile gene …
antibiotic resistance genes. IS 26 can recruit a gene or group of genes into the mobile gene …
Amikacin: uses, resistance, and prospects for inhibition
Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad
spectrum of bacterial infections. The primary resistance mechanism against these antibiotics …
spectrum of bacterial infections. The primary resistance mechanism against these antibiotics …
Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM
The mobile resistance gene bla NDM encodes the NDM enzyme which hydrolyses
carbapenems, a class of antibiotics used to treat some of the most severe bacterial …
carbapenems, a class of antibiotics used to treat some of the most severe bacterial …
Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131
Escherichia coli sequence type 131 (ST131) has emerged globally as the most predominant
extraintestinal pathogenic lineage within this clinically important species, and its association …
extraintestinal pathogenic lineage within this clinically important species, and its association …