Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

[HTML][HTML] From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways

Y Wang, TD Kanneganti - Computational and structural biotechnology …, 2021 - Elsevier
Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Immune regulation by fungal strain diversity in inflammatory bowel disease

XV Li, I Leonardi, GG Putzel, A Semon, WD Fiers… - Nature, 2022 - nature.com
The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial
community colonizing the mammalian gastrointestinal tract and has an important role in …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

SM Man, R Karki, TD Kanneganti - Immunological reviews, 2017 - Wiley Online Library
Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

The regulation of hyphae growth in Candida albicans

H Chen, X Zhou, B Ren, L Cheng - Virulence, 2020 - Taylor & Francis
In the last decades, Candida albicans has served as the leading causal agent of life-
threatening invasive infections with mortality rates approaching 40% despite treatment …

Interactions of fungal pathogens with phagocytes

LP Erwig, NAR Gow - Nature Reviews Microbiology, 2016 - nature.com
The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour
of phagocytic cells of the innate immune system, especially macrophages and neutrophils …

Immune defence against Candida fungal infections

MG Netea, LAB Joosten, JWM Van Der Meer… - Nature Reviews …, 2015 - nature.com
The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal …

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

L Kasper, A König, PA Koenig, MS Gresnigt… - Nature …, 2018 - nature.com
Clearance of invading microbes requires phagocytes of the innate immune system.
However, successful pathogens have evolved sophisticated strategies to evade immune …

Innate immune responses against the fungal pathogen Candida auris

Y Wang, Y Zou, X Chen, H Li, Z Yin, B Zhang… - Nature …, 2022 - nature.com
Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial
outbreaks worldwide. Although considerable progress has increased our understanding of …