Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life

TV Nguyen, G Damiani, LAV Orenstein… - Journal of the …, 2021 - Wiley Online Library
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs
patients' quality of life. It is characterized by recurrent painful nodules, abscesses and …

Hidradenitis suppurativa: epidemiology, clinical presentation, and pathogenesis

SR Goldburg, BE Strober, MJ Payette - Journal of the American Academy …, 2020 - Elsevier
Hidradenitis suppurativa (HS) is an inflammatory disorder that is characterized by chronic
deep-seated nodules, abscesses, fistulae, sinus tracts, and scars in the axilla, inguinal area …

Efficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double …

AB Kimball, GBE Jemec, CJ Sayed, JS Kirby, E Prens… - The Lancet, 2024 - thelancet.com
Background Patients with hidradenitis suppurativa have substantial unmet clinical needs
and scarce therapeutic options. We aimed to assess the efficacy and safety of bimekizumab …

Efficacy and safety of bimekizumab in moderate to severe hidradenitis suppurativa: a phase 2, double-blind, placebo-controlled randomized clinical trial

S Glatt, GBE Jemec, S Forman, C Sayed… - Jama …, 2021 - jamanetwork.com
Importance Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a high
burden for patients and limited existing therapeutic options. Objective To evaluate the …

Janus kinase 1 inhibitor INCB054707 for patients with moderate‐to‐severe hidradenitis suppurativa: results from two phase II studies

A Alavi, I Hamzavi, K Brown, LL Santos… - British Journal of …, 2022 - academic.oup.com
Background Janus kinase (JAK)‐mediated cytokine signalling contributes to local and
systemic inflammation in hidradenitis suppurativa (HS). Objectives To describe the safety …

Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa

K Navrazhina, JW Frew, P Gilleaudeau… - Journal of Allergy and …, 2021 - Elsevier
Background Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic,
painful, and burdensome inflammatory disease manifesting in nodules and abscesses, with …

Keratinocytes and immune cells in the epidermis are key drivers of inflammation in hidradenitis suppurativa providing a rationale for novel topical therapies

SL Schell, Z Cong, ML Sennett, SL Gettle… - British Journal of …, 2023 - academic.oup.com
Background Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disease
characterized by painful nodules, drainage and scarring in skin folds. Injectable adalimumab …

[HTML][HTML] Hidradenitis suppurativa is an autoinflammatory keratinization disease: a review of the clinical, histologic, and molecular evidence

JW Frew - JAAD international, 2020 - Elsevier
The pathogenic model of hidradenitis suppurativa is in the midst of a paradigm shift away
from a disorder of primary follicular occlusion to an autoinflammatory keratinization disease …

Hidradenitis suppurativa: current understanding of pathogenic mechanisms and suggestion for treatment algorithm

SM Seyed Jafari, RE Hunger, C Schlapbach - Frontiers in medicine, 2020 - frontiersin.org
Hidradenitis suppurativa is one of the most distressing dermatological conditions and has a
significant negative impact on patients' quality of life. However, the exact pathogenic …