Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

Viral pathogens often induce strong effector CD4+ T cell responses that are best known for
their ability to help B cell and CD8+ T cell responses. However, recent studies have …

We examined the regulation of virus-specific CD8 T cell responses during chronic
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …

Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are
presented on target cells by the class I major histocompatibility complex. CTLs are …

Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …

Technological advances in recent years have allowed for an ever-expanding ability to
analyze and quantify in vivo immune responses. MHC tetramers, intracellular cytokine …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Epstein-Barr virus (EBV) causes potentially lethal immunoblastic lymphoma in up to 25% of
children receiving bone marrow transplants from unrelated or HLA-mismatched donors …

Dendritic cells (DCs) express several receptors for the Fc portion of immunoglobulin (Ig) G
(FcγR), which mediate internalization of antigen–IgG complexes (immune complexes, ICs) …

Class I–restricted presentation is usually associated with cytoplasmic degradation of cellular
proteins and is often considered inaccessible to exogenous antigens. Nonetheless, certain …