The ubiquitin system
A Hershko, A Ciechanover - Annual review of biochemistry, 1998 - annualreviews.org
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …
[HTML][HTML] Biological and clinical aspects of HPV-related cancers
KA Szymonowicz, J Chen - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Cancer-related diseases represent the second overall cause of death worldwide. Human
papilloma virus (HPV) is an infectious agent which is mainly sexually transmitted and may …
papilloma virus (HPV) is an infectious agent which is mainly sexually transmitted and may …
Mechanisms underlying ubiquitination
CM Pickart - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-
associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and …
associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and …
Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade
UBIQUITINATION of proteins involves the concerted action of the El ubiquitin-activating
enzyme, E2 ubiquitin-conjugating enzymes and E3 ubiquitin–protein 1igases1–3. It has …
enzyme, E2 ubiquitin-conjugating enzymes and E3 ubiquitin–protein 1igases1–3. It has …
p53 and human cancer: the first ten thousand mutations
P Hainaut, M Hollstein - Advances in cancer research, 1999 - Elsevier
Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
KL Lorick, JP Jensen, S Fang… - Proceedings of the …, 1999 - National Acad Sciences
A RING finger-containing protein (AO7) that binds ubiquitin-conjugating enzymes (E2s) and
is a substrate for E2-dependent ubiquitination was identified. Mutations of cation …
is a substrate for E2-dependent ubiquitination was identified. Mutations of cation …
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
S Fang, JP Jensen, RL Ludwig, KH Vousden… - Journal of Biological …, 2000 - ASBMB
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …
Pathogenesis of human papillomaviruses in differentiating epithelia
MS Longworth, LA Laimins - Microbiology and molecular biology …, 2004 - Am Soc Microbiol
Human papillomaviruses (HPV) are the etiological agents of cervical and other anogenital
malignancies. Over 100 different types of HPVs have been identified to date, and all target …
malignancies. Over 100 different types of HPVs have been identified to date, and all target …
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system.
We have fractionated mitotic Xenopus egg extracts to identify components required for this …
We have fractionated mitotic Xenopus egg extracts to identify components required for this …