Transition metal complexes and photodynamic therapy from a tumor-centered approach: challenges, opportunities, and highlights from the development of TLD1433

S Monro, KL Colon, H Yin, J Roque III, P Konda… - Chemical …, 2018 - ACS Publications
Transition metal complexes are of increasing interest as photosensitizers in photodynamic
therapy (PDT) and, more recently, for photochemotherapy (PCT). In recent years, Ru (II) …

The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Potential-resolved ratiometric aptasensor for sensitive acetamiprid analysis based on coreactant-free electrochemiluminescence luminophores of Gd-MOF and “light …

J Li, Y Zhou, M **, L Hu, B Lu, W Gu, C Zhu - Analytical Chemistry, 2024 - ACS Publications
For conventional potential-resolved ratiometric electrochemiluminescence (ECL) systems,
the introduction of multiplex coreactants is imperative. However, the undesirable interactions …

Ruthenium (II) complexes with dppz: from molecular photoswitch to biological applications

G Li, L Sun, L Ji, H Chao - Dalton Transactions, 2016 - pubs.rsc.org
The DNA photoswitch [Ru (bpy) 2dppz] 2+(bpy= 2, 2′-bipyridine, dppz= dipyrido [3, 2-a:
2′, 3′-c] phenazine) has attracted much attention and become a powerful tool for studying …

Fluorescent functional nucleic acid: Principles, properties and applications in bioanalyzing

XX Wang, LJ Zhu, ST Li, YZ Zhang, SY Liu… - TrAC Trends in …, 2021 - Elsevier
Functional nucleic acids with fluorescence properties are powerful research tools for both
biomolecular analysis and biological nanomaterials. This review collected these interesting …

Highly selective mitochondrial targeting by a ruthenium (II) peptide conjugate: imaging and photoinduced damage of mitochondrial DNA

CS Burke, A Byrne, TE Keyes - Angewandte Chemie, 2018 - Wiley Online Library
Mitochondrial DNA (mtDNA) plays a crucial but incompletely understood role in cellular
biochemistry and etiology of numerous disease states. Thus, there is an urgent need for …

Anticancer screening of Ru (II) photoredox catalysts at single cancer cell level

Z Fan, J **e, R Kushwaha, S Liang, W Li… - Chemistry–An Asian …, 2023 - Wiley Online Library
The rapid efflux of Pt‐based chemotherapeutics by cancer cells is one of the major causes of
drug resistance in clinically available drugs. Therefore, both the high cellular uptake as well …

Photochemically active DNA-intercalating ruthenium and related complexes–insights by combining crystallography and transient spectroscopy

CJ Cardin, JM Kelly, SJ Quinn - Chemical science, 2017 - pubs.rsc.org
Recent research on the study of the interaction of ruthenium polypyridyl compounds and
defined sequence nucleic acids is reviewed. Particular emphasis is paid to complexes [Ru …

Strategies to promote permeation and vectorization, and reduce cytotoxicity of metal complex luminophores for bioimaging and intracellular sensing

L Holden, CS Burke, D Cullinane, TE Keyes - RSC Chemical Biology, 2021 - pubs.rsc.org
Transition metal luminophores are emerging as important tools for intracellular imaging and
sensing. Their putative suitability for such applications has long been recognised but poor …

Good Vibrations Report on the DNA Quadruplex Binding of an Excited State Amplified Ruthenium Polypyridyl IR Probe

M Stitch, D Avagliano, D Graczyk, IP Clark… - Journal of the …, 2023 - ACS Publications
The nitrile containing Ru (II) polypyridyl complex [Ru (phen) 2 (11, 12-dCN-dppz)] 2+(1) is
shown to act as a sensitive infrared probe of G-quadruplex (G4) structures. UV–visible …