Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …

Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on
the host cellular machinery to support their life cycle. Accordingly, identification of the host …

Since its identification in April 2009, an A (H1N1) virus containing a unique combination of
gene segments from both North American and Eurasian swine lineages has continued to …

Influenza A virus is an important human pathogen causing significant morbidity and mortality
every year and threatening the human population with epidemics and pandemics …

Many replication events are involved in the influenza A virus life cycle, and they are
accomplished by different virus proteins with specific functions. However, because the size …

Influenza A virus segment 2 is known to encode two polypeptides in overlap** open
reading frames: PB1, the polymerase, and PB1-F2, a proapoptotic virulence factor. We show …

The proapoptotic PB1-F2 protein of influenza A viruses has been shown to contribute to
pathogenesis in the mouse model. Expression of full-length PB1-F2 increases the …

The ability for a host to recognize infection is critical for virus clearance and often begins with
induction of inflammation. The PB1-F2 of pathogenic influenza A viruses (IAV) contributes to …

Transmission of influenza viruses into the human population requires surmounting barriers
to cross-species infection. Changes in the influenza polymerase overcome one such barrier …

Infection with Influenza A virus (IAV) causes significant cell death within the upper and lower
respiratory tract and lung parenchyma. In severe infections, high levels of cell death can …