Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021‏ - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis

Y Alnefeesi, D Chen-Li, E Krane, MY Jawad… - Journal of psychiatric …, 2022‏ - Elsevier
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …

Side-effects associated with ketamine use in depression: a systematic review

B Short, J Fong, V Galvez, W Shelker… - The Lancet Psychiatry, 2018‏ - thelancet.com
This is the first systematic review of the safety of ketamine in the treatment of depression
after single and repeated doses. We searched MEDLINE, PubMed, PsycINFO, and …

A consensus statement on the use of ketamine in the treatment of mood disorders

G Sanacora, MA Frye, W McDonald, SJ Mathew… - JAMA …, 2017‏ - jamanetwork.com
Importance Several studies now provide evidence of ketamine hydrochloride's ability to
produce rapid and robust antidepressant effects in patients with mood and anxiety disorders …

Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics

CG Abdallah, G Sanacora, RS Duman… - Annual review of …, 2015‏ - annualreviews.org
Ketamine is the prototype for a new generation of glutamate-based antidepressants that
rapidly alleviate depression within hours of treatment. Over the past decade, there has been …

A review of ketamine abuse and diversion

S Sassano‐Higgins, D Baron, G Juarez… - Depression and …, 2016‏ - Wiley Online Library
Ketamine was discovered in the 1960s and released for public use in 1970. Originally
developed as a safer alternative to phencyclidine, ketamine is primarily used in clinical …

NMDA receptors in the central nervous system

KB Hansen, F Yi, RE Perszyk, FS Menniti… - … receptors: Methods and …, 2017‏ - Springer
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: a randomized, double blind, placebo controlled trial

DF Ionescu, KH Bentley, M Eikermann, N Taylor… - Journal of affective …, 2019‏ - Elsevier
Background Several studies indicate that ketamine has rapid antidepressant effects in
patients with treatment-resistant depression (TRD). The extent to which repeated doses of …

Glutamatergic neurotransmission: pathway to develo** novel rapid-acting antidepressant treatments

B Kadriu, L Musazzi, ID Henter, M Graves… - International Journal …, 2019‏ - academic.oup.com
The underlying neurobiological basis of major depressive disorder remains elusive due to
the severity, complexity, and heterogeneity of the disorder. While the traditional …

Cognitive behavioral therapy to sustain the antidepressant effects of ketamine in treatment-resistant depression: a randomized clinical trial

ST Wilkinson, TG Rhee, J Joormann… - Psychotherapy and …, 2021‏ - karger.com
Introduction: Ketamine has emerged as a rapid-acting antidepressant. While ongoing
treatment can prevent relapse, concerns exist regarding long-term exposure. Objective: We …