Pregabalin and gabapentin share a similar mechanism of action, inhibiting calcium influx
and subsequent release of excitatory neurotransmitters; however, the compounds differ in …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

Although no randomized studies have demonstrated a positive impact of therapeutic drug
monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies …

Antiepileptic drugs (AEDs) are widely used as long-term adjunctive therapy or as
monotherapy in epilepsy and other indications and consist of a group of drugs that are …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

The Eigth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT VII, took place in
Sitges, Barcelona from the 10th to 14th September, 2006. Basic scientists, clinical …

Background: Pain is one of the most common reasons for seeking medical attention, and
neuropathic pain is among the most common types of pain. Despite its prevalence …

During the period 1989–2009, 14 new antiepileptic drugs (AEDs) were licensed for clinical
use and these can be subdivided into new second-and third-generation AEDs. The second …

Pregnancy is a state where pharmacokinetic changes are more pronounced and more rapid
than during any other period of life. The consequences of such changes can be far reaching …

The aim of the present review is to discuss the potential value of therapeutic drug monitoring
(TDM) of the newer antiepileptic drugs (AEDs) felbamate, gabapentin, lamotrigine …